What is Nattokinase? Exploring the Functional Wellness Properties of this Enzyme Unique to Natto
Natto, a traditional Japanese fermented food, is renowned not only for its distinct flavor but also for its remarkable nutritional profile. In this article, we delve into the science behind nattokinase, a natural enzyme found in natto, and explore how it supports healthy circulation, balanced blood pressure, and overall cardiovascular well-being for a modern, high-performance lifestyle.
What is Nattokinase and Why is it Unique to Bacillus Natto?
Nattokinase is a proteolytic enzyme (protease) produced exclusively by Bacillus natto during the natural fermentation of non-GMO soybeans. Recent scientific insights suggest that Bacillus natto may continue to provide benefits within the gastrointestinal tract after consumption.
This enzyme has attracted significant global attention for its role in supporting heart health and maintaining a balanced internal environment. Nattokinase primarily functions by supporting natural fibrinolysis—the body’s innate process for maintaining clear vascular pathways—which contributes to optimized cardiovascular health and enhanced systemic circulation.
What are the Historical and Scientific Origins of Nattokinase?
The presence of a powerful protease in natto was first reported by Dr. Sawamura in 1907. Subsequently, in 1925, Dr. Oshima of Hokkaido University discovered this protease’s ability to interact with fibrin. Detailed structural studies were conducted by Dr. Miyake et al. at Kobe University in the 1950s, followed by genetic analysis at Tohoku University in the 1990s.
Initially known as “natto protease,” it was officially named “nattokinase” by Dr. Sumi in the 1980s. In scientific literature today, it is referred to as subtilisin NAT.
How Does Nattokinase Support Functional Wellness?
Nattokinase possesses several notable health properties that contribute to its increasing popularity as a dietary supplement.
How Does it Support Healthy Circulation and Vascular Integrity?
Effective in Dissolving Clots and Preventing Thrombosis
Blood clots, known as thrombi, form within blood vessels in response to damage. These clots consist of platelets and fibrin, creating a seal to prevent further bleeding. Plasmin, a protease found in the human body, dissolves these clots during the wound-healing process.
Nattokinase exhibits a clot-dissolving power equal to or even 10 times stronger than plasmin, making it the most potent clot-dissolving enzyme known.
By promoting the breakdown of blood clots, nattokinase helps reduce the risk of thrombosis-related conditions such as myocardial infarction and cerebral infarction.
Hypertension Preventive Effects
Nattokinase has shown favorable effects on blood pressure regulation and hypertension prevention. It aids in the degradation of renin, a substance responsible for raising blood pressure, thereby helping prevent hypertension. Additionally, nattokinase and natto soybean decomposition products (natto peptides) inhibit the action of ACE (Angiotensin-converting enzyme), which narrows blood vessels, further contributing to the prevention of increased blood pressure levels.
Cholesterol-lowering effect
Studies have indicated that nattokinase plays a role in lowering cholesterol levels. This effect is believed to be a result of improved blood flow resulting from the breakdown of blood clots through the action of nattokinase. Furthermore, individuals consuming nattokinase have reported benefits such as reduced sensitivity to cold and alleviation of swelling.
Emerging Research Findings: Exciting new research has expanded our understanding of nattokinase’s potential benefits.
- Degradation of Amyloid β (Beta) and the Spike Protein of Covid-19: Recent studies have shown that nattokinase may have the ability to degrade amyloid β (beta), the causative agent of Alzheimer’s disease. Furthermore, preliminary research suggests that nattokinase can degrade the spike protein of the novel coronavirus (Covid-19). These findings open up new possibilities for the potential therapeutic applications of nattokinase.
- Cutting-Edge Research Applications: Nattokinase has been utilized in cutting-edge research projects, highlighting its versatility and potential beyond cardiovascular health. For instance, the Department of Ophthalmology at Kumamoto University has explored its use as an ophthalmic surgical aid in vitreous detachment procedures. Additionally, Michigan State University has employed nattokinase in the 3D culture of ES cells, demonstrating its value in various scientific fields.
Precautions when taking Nattokinase
While nattokinase offers significant health benefits, it is crucial to take precautions when obtaining it naturally from natto.
- Avoid Mixing Natto with Acidic Ingredients: Nattokinase is sensitive to acid and may break down when natto is mixed with vinegar, black vinegar, kimchi, or other acidic foods. To preserve the integrity of nattokinase, it is recommended to consume natto without combining it with acidic ingredients.
- Minimize Heating of Natto: Excessive heat can also degrade nattokinase. Therefore, it is advisable to avoid heating natto before consumption to retain the enzyme’s beneficial properties.
- Optimal Timing for Consumption: To maximize the thrombolytic (clot-dissolving) effect of nattokinase, consuming natto at dinner or before bedtime is considered more effective. During the early morning hours when the human biorhythm is at its lowest, blood clots are more likely to form. Taking nattokinase before bed can help prevent thrombosis in the early morning, safeguarding against related health risks.
In conclusion, nattokinase is a remarkable, food-derived enzyme that offers a natural path to supporting cardiovascular health and overall well-being. Ongoing research continues to uncover exciting possibilities for nattokinase’s therapeutic potential, including its role in degrading amyloid β (beta) and the spike protein of COVID-19.
With sonomono natto powder products you can harness the advantages of this traditional Japanese fermented food and easily incorporate it into your daily wellness routine.